Plasmonic optical fiber biosensor using human estrogen receptor α for ultrasensitive environmental estrogens detection (IMAGE)

Light Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS

Plasmonic optical fiber biosensor using human estrogen receptor α for ultrasensitive environmental estrogens detection

Caption

Sensing mechanism for detection of broad ranges of EEs by using human estrogen receptor α (hERα) as the biological recognition element. In brief, a gold-coated tilted fiber Bragg grating excites surface plasmon resonance (SPR) that enables the ultrasensitive monitoring of refractive index changes at the fiber surface. Environmental estrogens in the samples compete the hERα with the E2–STV conjugates. The fiber senor is tethered with the desthiobiotin (DTB) molecules and the unbound E2–STV conjugates are captured via the STV–DTB affinity interaction, which induces the wavelength shift of the SPR spectrum (from black to red). This method offers in situ detection of environmental estrogens with high sensitivity and specificity.

Credit

by Lanhua Liu, Xuejun Zhang, Qian Zhu, Kaiwei Li, Yun Lu, Xiaohong Zhou and Tuan Guo

Usage Restrictions

Credit must be given to the creator.

License

CC BY

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