(IMAGE)

Tokyo Medical and Dental University

Caption

Twenty-six patients with XIAP deficiency underwent HCT by the end of March 2020, and 22 (84.6%) survived. IBD improved remarkably after HCT. Gut microbiota indicated dysbiosis before HCT; however, it was improved to resemble that of the healthy family members after HCT. This study revealed that HCT has a favorable outcome for XIAP deficiency. HCT rescues gut inflammation and dysbiosis in patients with XIAP deficiency.

Credit

Department of Child Health and Development ,TMDU

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