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Mesenchymal stromal cells (MSCs) are potent immunomodulators that have shown promise in treating chronic obstructive pulmonary disease (COPD). Using transcriptomics, researchers have demonstrated that MSC infusions elicit a strong, yet transient (<7 days) transcriptional response in circulating mononuclear cells of COPD patients, attenuating key pro-inflammatory pathways. These responses are likely mediated by soluble factors and/or products of MSC breakdown.
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