Figure 1. Development of ALS (IMAGE) Niigata University Caption ALS-linked mutations of optineurin (OPTN) and depletion of OPTN delay clearance of SGs and increases ubiquitinated TDP-43 levels by increasing TIA1. Credit Niigata University Usage Restrictions The image may only be used with appropriate caption or credit. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.