Figure 6 (IMAGE)

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Figure 6

Caption

MDM2 can be targeted sarcoma cell lines independent of p53 status. (A) Expression of RABL6A, MDM2, YAP, TAZ, and p53 in sarcoma cell lines. (B) Cells were treated for 3 days with MA242 and analyzed with AlamarBlue (MTT-style proliferation assay); MA242 similarly inhibits proliferation in p53 wild-type and p53 null sarcoma cell lines. (C) Sarcoma cell lines most sensitive (drug response curves--black) and least sensitive (drug response curves--blue) to MA242 treatment. (D) Positive correlation of IC50 with MDM2 expression trends towards statistical significance.

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Correspondence to - Munir R. Tanas - munir-tanas@uiowa.edu

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Copyright: © 2021 Desai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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