Figure 1 (IMAGE)

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Figure 1

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Figure 1. Fibro-adipogenic progenitors (FAPs) dynamically cross-talk with the muscle stem cell (MuSC) niche to regulate regeneration and ECM/lipid turnover in different patho-physiologcal cues. (A) FAPs have distinct cellular fates and functions in different patho-physiological conditions; support to muscle fibers in homeostatic conditions [5]; support to muscle stem cells during regeneration [2]; pathological differentiation to fat and fibrosis [4,6]. (B) Aging alters the support of FAPs to MuSCs and regeneration and promotes their pathological skewing to fibrosis over adipogenesis [6].

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Jerome N. Feige Jerome.feige@rd.nestle.com

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