Figure 4 (IMAGE) Impact Journals LLC Caption LEC density is significantly reduced in the TME of sSCC with perineural infiltration (PNI). The frequency of CD8+ T cells in tumor (left) and stroma (right) tissue (A) and of LECs (B) of primary sSCC sections were compared in patients with (n = 16) versus without PNI (n = 20). (C) Stacked bar graphs showing the distribution of the four sSCC patient groups plotted according to the presence of high or low LEC density in primary tumor tissue. (D) LEC density in primary sSCC without metastases (n = 15), sSCC with PNI (n = 7), sSCC with metastases (n = 5) and sSCC with both metastases and PNI (n = 9). Bar graphs showing mean ? SD. *p < 0.05, **p < 0.01. Credit Correspondence to - Karin Schaeuble - karin.schauble@unil.ch Usage Restrictions Copyright: © 2021 Schaller et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.