Early-Life Intervention (IMAGE)
Caption
Early-life intervention with ctB rescues mice from age-associated obesity and inflammation. Shown are data collected from C57BL/6 mice of both genders at the age of 9 months. (a) At gross examination of whole body morphology, both female and male mice that consumed low doses of ctB eight months earlier have leaner physiques by comparison with untreated controls. (b) Treated mice also have less crown-like structures (CLS, arrow-heads), caused by adipocyte death-related inflammation, in their abdominal fat; (c) less myeloperoxidase-positive (MPO) granulocytes in their spleens; and (d) more anti-inflammatory Foxp3-positive regulatory T cells in their mesenteric lymph nodes compared to control mice. (e) Body weight and histomorphometrical analyses shows that the long-lasting effects of ctB are statistically significant. (a) Hematoxylin and Eosin. Scale bars: 250 μm. IHC; Diaminobenzidine chromogen, Hematoxylin counterstain. Scale bars: 25 μm. (b) Numbers on the y-axis of bar graphs correspond to the mean±SEM of the parameter assessed; *p<0.05, **p<0.01, ***p<0.001.
Credit
Susan E. Erdman - serdman@mit.edu
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ccby
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