Figure 1 (IMAGE)

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Figure 1

Caption

Schematic diagram of the human IGF2 gene structure. (A) The IGF2 gene diagram showing the relative positions of the IGF2 introns and coding exons. Also present in this region is the INS-IGF2 and the IGF2AS genes which code for non-translatable mRNAS. The newly identified differentially methylated region (DVDMR) is represented in red (chr11:2148098-2148354). This region is hypermethylated in normal breast tissues and hypomethylated in breast cancer. (B) Figure obtained from the UCSC Genome Browser, Dec. 2013 (GRCh38/hg38) showing in pink the DVDMR located between exon 1 and exon 2 of the IGF2 gene showing chr11:2148098 2148354 5?-3? pad strand = + sequence from Blat search in reference to human genome sequence; (C) INS-IGF2 DVDMR BLAT search sequence (chr11:2148098-2148354).

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Correspondence to - Daisy D. De León - ddeleon@llu.edu

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Copyright: © 2020 Radhakrishnan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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