Figure 4 (IMAGE)
Caption
Increased Trop-2 expression in MDA-MB-231 tumors overcomes resistance to SG but not irinotecan. NCr athymic nu/nu mice were injected s.c. with either MDA-MB-231 parental cells (parental), MDA-MB-231 clone 13 (C13) cells, or MDA-MB-231 clone 39 (C39) cells as described in Materials and Methods. Once tumors reached ~0.3 cm3 in size, mice were randomized into the various treatment groups. SG, control ADC, and parental hRS7 IgG antibody, were administered i.p., twice weekly for 4 weeks (black arrows). Irinotecan was administered i.v. at its MTD (q2dx5; red arrows). For all animal studies, the doses of SN-38 immunoconjugates and irinotecan are shown in SN-38 equivalents. The dose of hRS7 is shown at its protein dose equivalent to SG protein dose. Graphs to the left show mean tumor growth curves for each treatment group while those on the left indicate survival curves for these same groups of animals. **One mouse in SG group deemed an outlier via Grubbs' test and removed from final analysis. Grey dotted line in survival curves indicates 50% survival line.
Credit
Correspondence to - Thomas M. Cardillo - tcardillo@immunomedics.com
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Copyright: © 2020 Cardillo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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