Figure 4 (IMAGE)

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Figure 4

Caption

(A) Bimodal imaging examples of control and treated tumors (red) before and after the treatment period. cSCC tumors are red, reflectance is grayscale, and keratinocytes are green. All cSCC A431 cells are labeled with RFP while only 1% of keratinocytes are labeled with Zs-GFP resulting in sparsity of the green signal. (B) H&E, Ki67, and Anti-RFP antibody staining of untreated (control) tumor model and tumor model treated with 5FU for 48 hours. (C) 5FU treatment effect on tdT-RFP-labeled cSCC spheroids and Zs-GFP-labeled keratinocytes including p-value and effect size, δ. Two imaging biomarkers are shown, number of segmented objects and total fluorescence of the size-thresholded segmented objects. NOTE: the fluorescence in panel A is intentionally saturated for display.

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Correspondence to - Daniel S. Gareau - dgareau@rockefeller.edu.

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