Figure 6 (IMAGE)
Caption
Proposed mechanisms of tumor dissemination from primary breast tumors to metastases. CEACAM5-expression outlined as no expression (white circle), heterogeneous expression (half-filled grey circle) and homogeneous expression (filled grey circle) based on the observed expression patterns in a total of 59 sets of primary breast carcinomas (P) and corresponding lymph node metastases (M), including datasets from both cryosectioned tissue and TMA. The distribution of the 59 tumor sets are outlined along with a representative immunostain at the right, as well as the proportion of tumor-sets with the given profile. Hierarchy-locked suggests that the disseminating tumor cells remain in a specific differentiation state. Induced suggests that extrinsic factors lead to induction of CEACAM5 in negative cells. EMT and EMT/MET suggest that disseminating tumor cells undergo epithelial to mesenchymal transition (EMT) without or with subsequent mesenchymal to epithelial transition (MET), respectively. Hierarchy-based suggests that disseminating cancer stem cells retain their differentiation capacity.
Credit
Correspondence to - René Villadsen - r.villadsen@sund.ku.dk
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Copyright: © 2020 Bechmann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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