Figure 9 (IMAGE)
Caption
Figure 9: A schematic representation of the blood-brain barrier (BBB), brain around tumor region (BAT) and blood-tumor barrier (BTB) in late stage NSCLC brain metastases in an experimental model. (A) he BBB consists of endothelial cells (red), PDGFR-β-positive pericytes (blue) embedded in the endothelial (yellow) and astrocytic basement membranes (orange) enclosed by polarized astrocytic endfeet (brown) with aquaporin-4 water channels (green). (B) The tight junctions and basement membrane of the BAT were altered with an increase in claudin-5 protein, a loss of ZO-1 adapter protein and an increase in laminin-α2 protein in the astrocytic basement membrane. (C) In the BTB, there was a prominent loss of collagen IV in the endothelial basement membrane, PDGFR-β-positive pericytes and aquaporin-4 water channel protein. GFAP+ astrocytes (pink) and desmin+ contractile pericytes (purple) were identified throughout tumor-bearing brain sections.
Credit
L. Tiffany Lyle - tiffanylyle@purdue.edu
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