Figure 8 (IMAGE)
Caption
GA-OH activates p53 and Caspase 8 and induces apoptosis. (A) SCC19, SCC90 and SCC104 were seeded and treated with vehicle, 0.5 μM and 1 μM Of GA-OH for 24 hours. Activation of p53 was tested by blotting for p53 expression and activation. Caspase 8 activation and apoptosis was tested by blotting for Caspase 8 expression and activation of downstream targets. (B) Various HPV+ and HPV- cell lines were seeded in 96 well plates and treated with 0.75 uM GA-OH. Caspase 3/7 activity was measured after 24 hours. HPV+ cell lines show high levels of Caspase 3/7 activity.
Credit
Correspondence to - Penelope J. Duerksen-Hughes - pdhughes@llu.edu
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Copyright: © 2021 Chitsike et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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