Binding Activity of SEs (IMAGE)
Caption
PDAC cells demonstrated significant binding of different enhancers in PDAC cells than non-cancerous cells, (A) Binding with SOX2, FOXO-1, CDX-2, KLF-4, MED-1, PARD6B, KLF-7, MYC, OCT-4, SOX-9, USP12, INPP5D and (C) with SHH pathway using ChIP-Seq with the H3K27me3 antibody. (B and D) TCGA data also suggested a higher expression of those genes in PDAC compared with normal tissue.
Credit
Super-enhancers: novel target for pancreatic ductal adenocarcinoma https://doi.org/10.18632/oncotarget.26704 Animesh Dhar, email: adhar@kumc.edu
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