Effect of Extrinsic Warming of Low-Osmolality CT Contrast Media (Iohexol 350) on Extravasations and Patient Reaction Rates: A Retrospective Study (IMAGE)
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Key Finding: Among 3,939 patients who underwent CT using iohexol 350 prewarmed to body temperature, the adverse reaction rate was 0.28%, which was not significantly different (p=.69) from the reaction rate of 0.43% among 3,933 patients who received iohexol 350 maintained at room temperature; further analyses demonstrated noninferiority at 0.6% margin. Importance: The resources required to warm iohexol 350 to body temperature before injection for CT may not be warranted given the lack of observed practical benefit.
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American Roentgen Ray Society (ARRS), American Journal of Roentgenology (AJR)
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