Slipping Antibodies Into The Alzheimer's Brain (3 of 5) (VIDEO)

American Association for the Advancement of Science (AAAS)

Caption

Lower affinity antibodies against the transferring receptor, anti-TfR^D and anti-TfR/BACE1 (anti-TfR/BAC1) can cross the blood-brain barrier to reach neuronal targets in the brain as indicated by green staining around the neurons in red. This video relates to a paper that appeared in the May 25, 2011, issue of Science Translational Medicine, published by AAAS. The paper, by Dr. Y.J. Yu of Genentech Inc. in South San Francisco, Calif. and colleagues, was titled, “Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target.”

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Video © 2011 Genentech, Inc.

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