HPV vs Pap Test for Cervical Cancer Screening: Strong Evidence Calls for New Protocols, Say Experts (IMAGE)
Caption
The natural history, risk factors and opportunities for prevention of cervical cancer (HPV: Human Papillomavirus; HR-HPV: high oncogenic risk HPV). The blue boxes depict the natural history of cervical cancer carcinogenesis, from exposure to HPV, to acquisition and persistence of the infection, to pre-invasive lesions that may progress to invasive cervical cancer (ICC). For each step leading to ICC, only a fraction of cases progresses to the next step, whereas the majority will regress. The salmon boxes highlight some of the major risk factors for the initial contact with HPV and for the progression to subsequent steps. The green boxes indicate where opportunities for prevention lie.
Credit
Reproduced with permission from Tota et al., Prev Med 53: S12-S21, 2011.
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