First Inherited Mutation in SRC Cancer Gene Identified in Humans (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

First Inherited Mutation in SRC Cancer Gene Identified in Humans (1 of 2)

Caption

Mutant megakaryocytes, bone marrow cells that produce platelets, stained for SRC-419 show an abundance of rosette-like structures called podosomes. This material relates to a paper that appeared in the March 2, 2016, issue of Science Translational Medicine, published by AAAS. The paper, by E. Turro at University of Cambridge in Cambridge, UK, and colleagues was titled, 'A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.'

Credit

Kathleen Freson

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.