Prion Diseases (IMAGE) Cold Spring Harbor Laboratory Press Caption Confocal microscopy image reveals an intracellular neurofibrillary tangle (center; yellow-orange) and surrounding neurophil threads (magenta, orange, red and green) found in a human Alzheimer's disease brain postmortem. These hallmark pathological structures are composed of misfolded tau proteins double labeled by a monoclonal antibody and a fluorescent small-molecule amyloid-binding probe. Unaffected cells (white) and intracellular stress granules (blue) composed of lipofuscin are visualized adjacent to the pathologic tau deposits. This image was produced from a confocal "z-stack" consisting of numerous optical sections through 30 u.m of tissue and subsequently flattened using image-processing software. Credit Carlo Condello, University of California, San Francisco Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.