Prion Diseases (IMAGE)
Caption
Confocal microscopy image reveals an intracellular neurofibrillary tangle (center; yellow-orange) and surrounding neurophil threads (magenta, orange, red and green) found in a human Alzheimer's disease brain postmortem. These hallmark pathological structures are composed of misfolded tau proteins double labeled by a monoclonal antibody and a fluorescent small-molecule amyloid-binding probe. Unaffected cells (white) and intracellular stress granules (blue) composed of lipofuscin are visualized adjacent to the pathologic tau deposits. This image was produced from a confocal "z-stack" consisting of numerous optical sections through 30 u.m of tissue and subsequently flattened using image-processing software.
Credit
Carlo Condello, University of California, San Francisco
Usage Restrictions
None
License
Licensed content