Prion Protein Phase Separation (IMAGE)
Caption
The globular domain of the prion protein (PrP90-231), depicted in blue, binds different DNA aptamers, that have different conformations (hairpin, red; extended, black). Upon binding to these DNA sequences, PrP phase separates, and, depending on the conformation of the nucleic acid, a solid-like structure is formed (green), similar to the one found in the brain of carriers of neurodegenerative diseases related to protein misfolding, such as amyotrophic lateral sclerosis (ALS), and Parkinson's Disease.
Credit
Carolina Matos and Anderson Pinheiro
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