Designed Protein Sheds Light on Why Certain Proteins Act as Amyloids (IMAGE)

American Association for the Advancement of Science (AAAS)

Designed Protein Sheds Light on Why Certain Proteins Act as Amyloids

Caption

A synthetic amyloid peptide induces aggregation. We designed vascin, a synthetic amyloid peptide based on an amyloidogenic fragment of the signal peptide of VEGFR2. Vascin forms pefibrillar oligomers that penetrate mammalian cells and interacts with the nascent VEGFR2 protein, resulting in its aggregation and functional knockdown.

Credit

Image generated by Joost Schymkowitz, Rodrigo Gallardo and Frederic Rousseau

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