Driving Organoid Generation (IMAGE)

Cincinnati Children's Hospital Medical Center

Driving Organoid Generation

Caption

This image shows cultured two-dimensional human posterior gut endoderm cells (PGEC) that where genetically queued to drive the generation of three-dimensional hindgut spheroids and intestinal tissues. Scientists at the Cincinnati Children's Center for Stem Cell & Organoid Medicine and Yokohama City University publish data in Stem Cell Reports about a bioengineering strategy that uses induced pluripotent stem cells to generate PGECs. Researchers report they instructed the cells to form genetically stable gut and liver tissues that were of sufficient volume and size for viable transplant into patients.

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Cincinnati Children's

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