Figure (IMAGE) Kanazawa University Caption Role of ACSL1 in the CoA conjugation of propionic acid-class NSAIDs in liver. ACSL1, which showed the highest expression among ACS isoforms in human liver, selectively catalyzes propionic acid-class NSAIDs among various kinds of NSAIDs. Because the CoA conjugates with propionic acid-class NSAIDs had the ability of covalent binding to cellular proteins, they would be one of the causal factors inducing NSAIDs-induced toxicity. Credit Kanazawa University Usage Restrictions The image may only be used with appropriate caption and credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.