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Nara Institute of Science and Technology

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Shootin1a Is Required for Spine Structural Plasticity. Fluorescence time-lapse images of dendritic spines (A) and time course of their volume changes (B) of hippocampal neurons in slice culture. Spines were stimulated by local application of a neurotransmitter glutamate for 30 s (red asterisks). 30-sec stimulation of control spines induced their rapid enlargement which persisted for more than 30 min (blue arrows, top). Downregulation of shootin1a significantly inhibited the spine enlargement (middle). Furthermore, re-addition of shootin1a rescued the reduction of the spine enlargement (blue arrows, bottom), thereby indicating that shootin1a plays an essential role in spine structural plasticity.

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Naoyuki Inagaki

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