How Membrane Receptors Are Blocked (IMAGE) University of the Basque Country Caption The activation of the intracellular signalling of the IFN-gR receptor depends on the lipid nanodomains present in the membrane. The alteration of these nanodomains or the presence of a single mutation in the receptor induces galectin binding. The receptor ends up trapped in the actin filaments and cell signalling is blocked. Credit Instituto Biofisika (UPV/EHU, CSIC) Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.