3D Structure of Mgm1 (IMAGE)

Max Delbrück Center for Molecular Medicine in the Helmholtz Association

3D Structure of Mgm1

Caption

Mitochondria are not rigid organelles - they continuously divide and fuse with each other. A key player of this process is Mgm1, a protein of the dynamin family. Using the technique of X-ray crystallography, the team was able to determine the protein's three-dimensional structure: the motor (the GTPase domain, orange), the lever (the BSE domain, red), the stalk (blue) and the newly discovered paddle (green). Combining these results with cryo-EM data, yeast growth and fluorescence microscopy data from cooperation partners, we were able to propose molecular models demonstrating how Mgm1 filaments stabilise and remodel the inner membrane of mitochondria.

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Daumke Lab, MDC

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