MEMOIR Cells (IMAGE)
Caption
MEMOIR enables the histories of cells to be recorded in their genomes and then read out using microscopy. Here, MEMOIR cells were variably activated, as seen by the bright cyan nuclear fluorescence in some cells. The cells recorded information in response to this signal with the help of a DNA-editing system called CRISPR. This recorded information can then be read out using a technique called seqFISH to visualize certain RNA transcripts in the cells (red dots).
Credit
Elowitz and Cai Labs/Caltech
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