Gene Therapy Regenerates Diseased Liver in Pigs (2 of 3) (IMAGE)

American Association for the Advancement of Science (AAAS)

Gene Therapy Regenerates Diseased Liver in Pigs (2 of 3)

Caption

Representative liver tissues from pigs stained for FAH at the time of hepatectomy (left panels) and 12 months after transplantation with LV-Fah-transduced hepatocytes (middle and right panels). An age-matched, nontreated control wild-type (WT) pig is shown for comparison. Highmagnification images of the regions outlined by dotted squares are provided. This material relates to a paper that appeared in the July 27, 2016, issue of Science Translational Medicine, published by AAAS. The paper, by R.D. Hickey at Mayo Clinic in Rochester, MN, and colleagues was titled, 'Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1.'

Credit

Hickey <i>et al., Science Translational Medicine</i> (2016)

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