Medial Orbitofrontal Cortex (IMAGE) PLOS Caption The same areas of the brain-the medial orbitofrontal cortex-are engaged when people receive a reward or avoid a negative outcome. Credit Image: O'Doherty et al. Usage Restrictions Please cite the authors and PLoS Biology as the source. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.