Network topology (IMAGE)

Buck Institute for Research on Aging

Network topology

Caption

Network topology analysis of immune system function representing dozens of integrated cellular responses that are rewired during removal of the hepatitis C virus in humans. Different communities (functional clusters, colored) are determined by the signaling pathways that are being interrogated. For example the black community observed during active HCV infection is largely configured by MAPK activity; shrinks with the decrease in viremia, and disappears after complete viral clearance. A nascent blue population mid-treatment configured by proliferation/survival/differentiation (P/S/D)/STAT1 signaling activities (largely anti-viral) expands post sofosbuvir treatment.

Credit

Dr. David Furman

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