Enzymes USP28 and USP25 (IMAGE)

University of Würzburg

Enzymes USP28 and USP25

Caption

Structures of the catalytic domains of USP28 and USP25: USP28 is a constitutively active dimer and can bind and process ubiquitin (orange) at any time. In contrast, USP25 is a tetramer composed of two inter-linked USP28-like dimers (blue / gray and yellow / green) and this arrangement prevents binding of the substrate rendering the enzyme inactive.

Credit

Picture: Rudolf Virchow Center of experimental biomedicine / University of Wuerzburg

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