Hydrogen-Bonding Pairing Helps Design Better Drugs to Neutralize Gut Bacterial Infections (IMAGE)

Baylor College of Medicine

Hydrogen-Bonding Pairing Helps Design Better Drugs to Neutralize Gut Bacterial Infections

Caption

IP6, the natural inhibitor or ligand of Clostridium difficile's toxin, binds weakly to the toxin. This results in the toxin remaining active (center figure). Changing a single atom in IP6 to form IP6(S) results in stronger binding to the toxin and its inactivation (left side figure).

Credit

T. Savidge (BCM); K. Prince (TCH)

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