How Baby Neurons Leave the Nest (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

How Baby Neurons Leave the Nest (1 of 2)

Caption

Famulski et al. analyze how an antagonistic relationship between the Seven in Absentia Homolog ubiquitin ligase and the PAR complex controls radial migration initiation by regulating adhesion of neuronal and glial cells during germinal zone exit. The three-dimensional rendering shows the interface of a live cerebellar granule neuron (labeled with Junctional Adhesion Molecule-C pHluorin and Histone 2B-mTagBFP) with a live cerebellar glial cell (labeled with Junctional Adhesion Molecule-B mNectarine) in vitro. The green and red signals arise from fluorescent labeling of the cognate adhesion receptor expressed on the neuronal or glial surfaces. This image relates to an article that appeared in the Nov. 25, 2010, issue of Science Express, published by AAAS. The study, by Dr. Jakub Famulski at St. Jude Children’s Research Hospital in Memphis, TN, and colleagues was titled, "Siah Regulation of Pard3A Controls Neuronal Cell Adhesion During Germinal Zone Exit."

Credit

[Image courtesy of Jennifer Peters and David Solecki, St Jude Children's Research Hospital]

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