Schematic Diagram of Pathological Changes in Corneal Angiogenesis (IMAGE)

Kumamoto University

Schematic Diagram of Pathological Changes in Corneal Angiogenesis

Caption

DSCR-1 acts as a brake against abnormal NFAT activation and oxidative stress, but if it does not work, high cholesterol increases LDL oxidation (OxLDL), SDF-1/CXCR4 signaling in the endothelium is activated, and VEGF production in macrophages increases. These activations result in vascular invasion of the normally vascular-free and clear cornea, resulting in opacity (clouding).

Credit

Professor Takashi Minami

Usage Restrictions

<p>Fig. 5(G) of <a href="https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315003">Muramatsu, M. et al. (2020). Loss of Down Syndrome Critical Region-1 Mediated-Hypercholesterolemia Accelerates Corneal Opacity Via Pathological Neovessel Formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(10), 2425-2439. doi:10.1161/atvbaha.120.315003</a>. </p> <p>Use of the material in any format is prohibited without written permission from the publisher, Wolters Kluwer Health, Inc. Please contact permissions@lww.com for further information. </p>

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.