Synaptic Disorder (IMAGE) University of Würzburg Caption This is an electron microscope image of synaptic vesicles in the axon terminals of reference motor neurons (left) and Plekhg5-deficient motor neurons (right) at 100,000x magnification. Dysfunctional synaptic vesicles that are degraded in healthy individuals accumulate in Plekhg5-deficient motor neurons and lead to functional loss of synaptic transmission. Such dysfunctional, enlarged vesicles are marked with asterisks. Credit (Picture: Peter Heimann) Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.