Why Does Inflammation Enhance Pain Relief from Opioids? (1 of 2) (IMAGE)

American Association for the Advancement of Science (AAAS)

Why Does Inflammation Enhance Pain Relief from Opioids? (1 of 2)

Caption

Activating the TRPV1 channel (red) with the inflammatory molecule capsaicin promoted the movement of the beta-arrestin2 protein to the nucleus in human kidney cells. This material relates to a paper that appeared in the April 2, 2019, issue of Science Signaling, published by AAAS. The paper, by L. Basso at Alberta Children's Hospital Research Institute in Calgary, AB, Canada; and colleagues was titled, "TRPV1 promotes opioid analgesia during inflammation."

Credit

L. Basso <i>et al., Science Signaling </i>(2019)

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.