Temozolomide Gliomas, CNIO (IMAGE)

Centro Nacional de Investigaciones Oncológicas (CNIO)

Temozolomide Gliomas, CNIO

Caption

Glioma cells (in blue) under temozolomide treatment, with DNA damage marked in brown. When the MGMT locus is intact, MGMT expression is silenced and temozolomide promotes DNA damage all over the tumour cells (left); when the MGMT locus is rearranged, glioma cells overexpress MGMT, can repair the damage and keep growing (right).

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CNIO

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