Health Benefits of 5 Percent Weight Loss (IMAGE) Cell Press Caption Magkos et al. demonstrate the profound therapeutic effects of weight loss on metabolic function in subjects with obesity. This visual abstract shows how even a moderate 5% weight loss has considerable health benefits, including decreased intra-abdominal and intra-hepatic fat and increased multiorgan insulin sensitivity and b cell function. Additional weight loss further improves many cardiometabolic outcomes. Credit Magkos et al./Cell Metabolism 2016 Usage Restrictions Credit Required. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.