HCN4 and Heart Failure (IMAGE) Hiroshima University Caption The HCN4 SNP rs7164883 independently increases risk of heart failure in patients with atrial fibrillation. Credit Hiroshima University Usage Restrictions This image may only be used with appropriate caption or credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.