Humanized Mouse Model and Liraglutide (IMAGE) Cell Press Caption This visual abstract depicts the work Abdulreda et al. Using a humanized mouse model, they show that, following the initial improvement in human pancreatic function, prolonged daily liraglutide treatment for over 200 days is associated with compromised insulin release and dysregulated glucose homeostasis, indicating islet cell metabolic exhaustion. Credit Abdulreda et al./<i>Cell Metabolism</i> 2016 Usage Restrictions Credit Required. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.