Intergenerational Effects of Paternal Psych Stress (IMAGE)

Cell Press

Intergenerational Effects of Paternal Psych Stress

Caption

This visual abstract shows how using a mouse model of restraint stress, Wu et al. uncovered the intergenerational effects of paternal psychological stress on glucose metabolism in offspring. Paternal stress epigenetically downregulates miR-466b-3p expression, leading to increased PEPCK expression and hepatic gluconeogenesis in hyperglycemic F1 mice.

Credit

Wu, Lu, and Jiao et al./Cell Metabolism 2016

Usage Restrictions

Credit Required.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.