Modified RNA Transfection Corrects Barth Syndrome Dysfunction (IMAGE)

Harvard University

Modified RNA Transfection Corrects Barth Syndrome Dysfunction

Caption

Researchers use modified RNA transfection to correct genetic dysfunction in heart stem cells derived from Barth syndrome patients. The series of images show how inserting modified RNA into diseased cells causes the cells to produce functioning versions of the TAZ protein (first image: in green) that correctly localize in the mitochondria (second image: in red). When the images are merged to demonstrate this localization, green overlaps with red, giving the third image a yellow color.

Credit

Gang Wang and William Pu/Boston Children's Hospital

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