Molecular Mayhem (IMAGE)

Cincinnati Children's Hospital Medical Center

Molecular Mayhem

Caption

In this microscopic image, brain cells from adult mice are shown expressing the protein Olig2 (shown in red). Researchers at Cincinnati Children's Hospital Medical Center report May 9 in Cancer Cell that Olig2 contributes to the transformation of normal brain precursor cells into abnormal malignant cells that divide uncontrollably. They also show that Olig2 is the molecular arbiter of genetic adaptability that makes high-grade gliomas aggressive and treatment resistant. Inhibiting Olig2 in tumor forming cells changed their composition and sensitized them to targeted molecular treatment.

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Cincinnati Children's

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