TOP2A Relieves Negative Supercoiling at Gene Promoters, Which Prevents the Advance RNA Polymerase (IMAGE)

Centro Nacional de Investigaciones Oncológicas (CNIO)

TOP2A Relieves Negative Supercoiling at Gene Promoters, Which Prevents the Advance RNA Polymerase

Caption

TOP2A relieves negative supercoiling at gene promoters, resulting thus in an increase in the number of twists of the DNA strands. This is an obstacle to the continuous opening of the helix that prevents the advance RNA polymerase, remaining in a poised state ready to trigger gene expression as soon as needed.

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CNIO

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