Aneuploidy -- Causes and Consequences (1 of 9) (IMAGE)

American Association for the Advancement of Science (AAAS)

Aneuploidy -- Causes and Consequences (1 of 9)

Caption

Visualization of chromatin structure in the nucleus of STAG2-deficient cancer cells using Hoechst stain that binds to genomic DNA. The cell in the center of the image is in the late prophase stage of mitosis where the chromatids have fully condensed but have not yet begun to pull apart into two daughter cells. One of the chromatids has improperly condensed which will result in an abnormal separation of the chromosomes leading to a chromosomal break or abnormal chromosome number (aneuploidy). Several interphase cells not in the process of dividing can also be seen. This image relates to an article that appeared in the Aug. 19, 2011, issue of Science, published by AAAS. The study, by Dr. D.A. Solomon of the Georgetown University School of Medicine in Washington, D.C., and colleagues was titled, "Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer."

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