Mapping Gene Regulation (IMAGE)

Cincinnati Children's Hospital Medical Center

Mapping Gene Regulation

Caption

Scientists report in Genome Research a new mathematical method that makes it easier to conduct more of the complex data analysis needed to advance the exploding field of personalized medicine. They were able to use vastly less biological material to identify a network of protein transcription factors (TFs) that regulate the function of T Helper 17 (TH17) cells, an immune cell type that defends against bacterial and fungal infections but also can lead to autoimmune diseases when malfunctioning. In this image, bolded gene names correspond to transcription factors (TFs). Connections between TFs and genes are colored red for activation or blue for inhibition of gene expression.

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Cincinnati Children's

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