Proteins (IMAGE)

The University of Hong Kong

Proteins

Caption

(a) Exploration of Ag+-binding proteins in the soluble fraction of S. aureus with LC-GE-ICP-MS. (b) The overall structure of Ag-bound 6PGDH. (c) Silver coordination sites in 6PGDH and silver cluster composed of four adjacent Ag ions. (d) Diagram showing that Ag+ kills S. aureus by targeting multiple essential pathways. (e) Isobolograms of the combination of conventional antibiotics and Ag+ against S. aureus Newman. (f) Resistance acquisition curves during serial passage with the subinhibitory concentration of ampicillin or combination of ampicillin and Ag+ against S. aureus Newman.

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The University of Hong Kong

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