Magnus Kjærgaard and Mateusz Dyla (IMAGE) Aarhus University Caption Magnus Kjærgaard (left) and Mateusz Dyla challenge one of the cornerstones of biochemistry, the Michaelis-Menten equation as they show that many enzymes in signalling pathways are independent of substrate concentration, because the substrate is physically connected to the enzyme. Credit Mateusz Dyla Usage Restrictions Image may be used only to illustrate the research described in the accompanying release. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.