Immunofluorescence (IMAGE)
Caption
Immunofluorescence staining shows that genotoxic colibactin-producing E. coli (green) cause DNA damage (indicated by the presence of the DNA repair protein γH2AX, white) and megalocytosis (abnormal enlargement of cells) (right). This is not observed for cells infected with a mutant E. coli strain (E. coli ΔclbR) that is defective for colibactin synthesis (left). Phalloidin (red) stains for actin filaments of the cells and DNA is shown in blue.
Credit
Max Planck Institute for Infection Biology / Amina Iftekhar
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